Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial

Author:

Wolfe Gil I,Kaminski Henry J,Aban Inmaculada B,Minisman Greg,Kuo Hui-Chien,Marx Alexander,Ströbel Philipp,Mazia Claudio,Oger Joel,Cea J Gabriel,Heckmann Jeannine M,Evoli Amelia,Nix Wilfred,Ciafaloni Emma,Antonini Giovanni,Witoonpanich Rawiphan,King John O,Beydoun Said R,Chalk Colin H,Barboi Alexandru C,Amato Anthony A,Shaibani Aziz I,Katirji Bashar,Lecky Bryan R F,Buckley Camilla,Vincent Angela,Dias-Tosta Elza,Yoshikawa Hiroaki,Waddington-Cruz Márcia,Pulley Michael T,Rivner Michael H,Kostera-Pruszczyk Anna,Pascuzzi Robert M,Jackson Carlayne E,Verschuuren Jan J G M,Massey Janice M,Kissel John T,Werneck Lineu C,Benatar Michael,Barohn Richard J,Tandan Rup,Mozaffar Tahseen,Silvestri Nicholas J,Conwit Robin,Sonett Joshua R,Jaretzki Alfred,Newsom-Davis John,Cutter Gary R,Cutter Gary,Aban Inmaculada,Minisman Greg,Feese Michelle,Kuo Hui-Chien,Newsom-Davis John,Wolfe Gil,Kaminski Henry,Jaretzki Alfred,Sonett Joshua,Mazia Claudio,Saluto Valeria,Rosenberg Moises,Alvarez Valeria,Rey Lisa,King John,Butzkueven Helmut,Goldblatt John,Carey John,Pollard John,Reddel Stephen,Handel Nicholas,McCaughan Brian,Pallot Linda,Waddington-Cruz Márcia,Novis Ricardo,Boasquevisque Carlos,Dias-Tosta Elza,Morato-Fernandez Rubens,Ximenes Manoel,Werneck Lineu,Scola Rosana,Soltoski Paulo,Chalk Colin,Moore Fraser,Mulder David,Wadup Lisa,Oger Joel,Mezei Michele,Evans Kenneth,Jiwa Theresa,Schaffar Anne,White Chris,Toth Cory,Gelfand Gary,Wood Susan,Pringle Elizabeth,Zwicker Jocelyn,Maziak Donna,Shamji Farid,Sundaresan Sudhir,Seely Andrew,Cea Gabriel,Verduga Renato,Aguayo Alberto,Jander Sebastian,Zickler Philipp,Klein Michael,Marx Alexander,Ströbel Philipp,Weis Cleo-Aron,Melms Arthur,Bischof Felix,Aebert Hermann,Ziemer Gerhard,Nix Wilfred,Thümler Björn,Wilhem-Schwenkmezger Thomas,Mayer Eckhard,Schalke Berthold,Pöschel Peter,Hieber Gisela,Wiebe Karsten,Antonini Giovanni,Clemenzi Alessandro,Ceschin Vanessa,Rendina Erino,Venuta Federico,Morino Stefania,Bucci Elisabetta,Durelli Luca,Tavella Alessia,Clerico Marinella,Contessa Giulia,Borasio Piero,Evoli Amelia,Servidei Serenella,Granone Pierluigi,Mantegazza Renato,Berta Emilia,Novellino Lorenzo,Spinelli Luisa,Motomura Masakatsu,Matsuo Hidenori,Nagayasu Takeshi,Yoshikawa Hiroaki,Takamori Masaharu,Oda Makoto,Matsumoto Isao,Furukawa Yutaka,Noto Daisuke,Motozaki Yuko,Iwasa Kazuo,Yanase Daisuke,Garcia Ramos Guillermo,Cacho Bernardo,de la Garza Lorenzo,Kostera-Pruszczyk Anne,Lipowska Marta,Kwiecinski Hubert,Potulska-Chromik Anna,Orlowski Tadeusz,Silva Ana,Feijo Marta,Freitas António,Heckmann Jeannine,Frost Andrew,Pan Edward,Tucker Lawrence,Rossouw Johan,Drummond Fiona,Illa Isabel,Diaz Jorge,Leon Carlos,Yeh Jiann-Horng,Chiu Hou-Chang,Hsieh Yei-San,Witoonpanich Rawiphan,Tunlayadechanont Supoch,Attanavanich Sukasom,Verschuuren Jan,Straathof Chiara,Titulaer Maarten,Versteegh Michel,Pels Arda,Krum Yvonne,Buckley Camilla,Leite M. Isabel,Vincent Angela,Hilton-Jones David,Ratnatunga Chandi,Farrugia Maria,Petty Richard,Overell James,Kirk Alan,Gibson Andrew,McDermott Chris,Hopkinson David,Lecky Bryan,Watling David,Marshall Dot,Saminaden Sam,Davies Deborah,Dougan Charlotte,Sathasivam Siva,Page Richard,Sussman Jon,Ealing John,Krysiak Peter,Amato Anthony,Salajegheh Mohammad,Jaklitsch Michael,Roe Kristen,Ashizawa Tetsuo,Smith Robert Glenn,Zwischenberg Joseph,Stanton Penny,Barboi Alexandru,Jaradeh Safwan,Tisol William,Gasparri Mario,Haasler George,Yellick Mary,Dennis Cedric,Barohn Richard,Pasnoor Mamatha,Dimachkie Mazen,McVey April,Gronseth Gary,Dick Arthur,Kramer Jeffrey,Currence Melissa,Herbelin Laura,Belsh Jerry,Li George,Langenfeld John,Mertz Mary Ann,Benatar Michael,Harrison Taylor,Force Seth,Usher Sharon,Beydoun Said,Lin Frank,DeMeester Steve,Akhter Salem,Malekniazi Ali,Avenido Gina,Crum Brian,Milone Margherita,Cassivi Stephen,Fisher Janet,Ciafaloni Emma,Heatwole Chad,Watson Thomas,Hilbert James,Smirnow Alexis,Distad B. Jane,Weiss Michael,Wood Douglas,Haug Joanna,Ernstoff Raina,Cao Jingyang,Chmielewski Gary,Welsh Robert,Duris Robin,Gutmann Laurie,Pawar Gauri,Graeber Geoffrey Marc,Altemus Patricia,Nance Christopher,Gutmann Ludwig,Jackson Carlayne,Grogan Patrick,Calhoon John,Kittrell Pamela,Myers Deborah,Hayat Ghazala,Naunheim Keith,Eller Susan,Holzemer Eve,Katirji Bashar,Alshekhlee Amer,Robke Jason,Karlinchak Brenda,Katz Jonathan,Miller Robert,Roan Ralph,Forshew Dallas,Kissel John,Elsheikh Bakri,Ross Patrick,Chelnick Sharon,Lewis Richard,Acsadi Agnes,Baciewicz Frank,Masse Stacey,Massey Janice,Juel Vern,Onaitis Mark,Lowe James,Lipscomb Bernadette,Mozaffar Tahseen,Thai Gaby,Milliken Jeffrey,Martin Veronica,Karayan Ronnie,Muley Suraj,Parry Gareth,Shumway Sara,Oh Shin,Claussen Gwen,Lu Liang,Cerfolio Robert,Young Angela,Morgan Marla,Pascuzzi Robert,Kincaid John,Kesler Kenneth,Guingrich Sandy,Michaels Angi,Phillips Lawrence,Burns Ted,Jones David,Fischer Cindy,Pulley Michael,Berger Alan,D'Agostino Harry,Smith Lisa,Rivner Michael,Pruitt Jerry,Landolfo Kevin,Hillman Demetric,Shaibani Aziz,Sermas Angelo,Ruel Ross,Ismail Farah,Sivak Mark,Goldstein Martin,Camunas Jorge,Bratton Joan,Tandan Rup,Panitch Hill,Leavitt Bruce,Jones Marilee,Muppidi Srikanth,Vernino Steven,Nations Sharon,Meyer Dan,Gorham Nina

Funder

US National Institutes of Health awarded to the University of Alabama at Birmingham

University of Kansas Medical Centre for Frontiers: the Heartland Institute for Clinical and Translational Research

University at Buffalo State University of New York

University of Texas Health Science Center at San Antonio

Publisher

Elsevier BV

Subject

Clinical Neurology

Reference25 articles.

1. The treatment of myasthenia gravis by removal of the thymus gland;Blalock;JAMA,1941

2. Thymectomy for non-thymomatous autoimmune myasthenia gravis (an evidence-based review);Gronseth;Neurology,2000

3. Thymectomy for non-thymomatous myasthenia gravis;Cea;Cochrane Database Syst Rev,2013

4. Randomised trial of thymectomy in myasthenia gravis;Wolfe;N Engl J Med,2016

5. Observations of the natural history of myasthenia gravis and the effect of thymectomy;Oosterhuis;Ann NY Acad Sci,1981

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