Efficacy of National Comprehensive Cancer Network Guidelines in Identifying Pathogenic Germline Variants Among Unselected Patients with Prostate Cancer: The PROCLAIM Trial

Author:

Shore Neal,Gazi Mukaram,Pieczonka Christopher,Heron Sean,Modh Rishi,Cahn David,Belkoff Laurence H.,Berger Aaron,Mazzarella Brian,Veys Joseph,Idom Charles,Morris David,Jayram Gautam,Engelman Alexander,Bukkapatnam Raviender,Dato Paul,Bevan-Thomas Richard,Cornell Robert,Wise David R.,Hardwick Mary Kay,Hernandez Ryan D.,Rojahn Susan,Layman Paige,Hatchell Kathryn E.,Heald Brandie,Nussbaum Robert L.,Nielsen Sarah M.,Esplin Edward D.ORCID

Publisher

Elsevier BV

Subject

Urology,Radiology, Nuclear Medicine and imaging,Oncology,Surgery

Reference36 articles.

1. Prostate cancer in male BRCA1 and BRCA2 mutation carriers has a more aggressive phenotype;Mitra;Br J Cancer,2008

2. Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer;Castro;J Clin Oncol,2013

3. Germline mutations in ATM and BRCA1/2 distinguish risk for lethal and indolent prostate cancer and are associated with early age at death;Na;Eur Urol,2017

4. Center for Drug Evaluation and Research. FDA approves olaparib for HRR gene-mutated metastatic castration-resistant prostate cancer. https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-olaparib-hrr-gene-mutated-metastatic-castration-resistant-prostate-cancer.

5. Center for Drug Evaluation and Research. FDA grants accelerated approval to rucaparib for BRCA-mutated metastatic castration-resistant prostate cancer. https://www.fda.gov/drugs/fda-grants-accelerated-approval-rucaparib-brca-mutated-metastatic-castration-resistant-prostate.

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