Non-clinical pharmacokinetics and pharmacodynamics of rVIII-SingleChain, a novel recombinant single-chain factor VIII
Author:
Funder
CSL Behring GmbH
Publisher
Elsevier BV
Subject
Hematology
Reference34 articles.
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4. Impact of inhibitor epitope profile on the neutralizing effect against plasma-derived and recombinant factor VIII concentrates in vitro;Astermark;Haemophilia,2003
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1. Plasma Clearance of Coagulation Factor VIII and Extension of Its Half-Life for the Therapy of Hemophilia A: A Critical Review of the Current State of Research and Practice;International Journal of Molecular Sciences;2023-05-11
2. A French Real-World Evidence Study Evaluating the Efficacy, Safety, and Pharmacokinetic Parameters of rVIII-SingleChain in Patients with Hemophilia A Receiving Prophylaxis;Thrombosis and Haemostasis;2023-02-09
3. Clinical experience of switching patients with severe hemophilia to rVIII-SingleChain or rIX-FP;Current Medical Research and Opinion;2022-09-28
4. Pharmacokinetic analysis identifies a factor VIII immunogenicity threshold after AAV gene therapy in hemophilia A mice;Blood Advances;2022-04-22
5. Recombinant single‐chain factor VIII in severe hemophilia: Long‐term safety and efficacy in previously treated patients in the AFFINITY extension study;Research and Practice in Thrombosis and Haemostasis;2022-02
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