Syk inhibition suppresses NLRP3 inflammasome activation in platelets from sickle cell mice leading to decreased platelet secretion, aggregation, spreading, and in vitro thrombus formation
Author:
Funder
Clinical Center
US Government National Institutes of Health
Publisher
Elsevier BV
Reference10 articles.
1. Interplay between coagulation and vascular inflammation in sickle cell disease;Sparkenbaugh;Br. J. Haematol.,2013
2. The NLRP3 inflammasome and bruton’s tyrosine kinase in platelets co-regulate platelet activation, aggregation, and in vitro thrombus formation;Murthy;Biochem. Biophys. Res. Commun.,2017
3. NLRP3 regulates platelet integrin alphaIIbbeta3 outside-in signaling, hemostasis and arterial thrombosis;Qiao;Haematologica,2018
4. The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase;Vogel;Blood Adv.,2018
5. NLRP3 inflammasome and bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice;Vogel;Biochem. Biophys. Res. Commun.,2021
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