Beware of Clinical Trials of DNA Repair Inhibitors
Author:
Publisher
Elsevier BV
Subject
Cancer Research,Radiology Nuclear Medicine and imaging,Oncology,Radiation
Reference5 articles.
1. Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair;Biedermann;Proc Natl Acad Sci USA,1991
2. Highly potent and selective DNA-PK inhibitor M3814 with sustainable anti-tumor activity in combination with radiotherapy (abstract);Fuchss;Cancer Res,2017
3. Recent disclosures of clinical candidates: Highlights from the society of medicines research symposium;Hann;Drugs of the Future,2017
4. Safety, clinical activity and pharmacological biomarker evaluation of the DNA-dependent protein kinase (DNA-PK) inhibitor M3814: Results from two phase I trials;Mau-Sorensen;Ann Oncol,2018
5. Hypoxia-selective DNA-PK inhibitor [abstract];Kyle;Mol Cancer Ther,2018
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