A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer

Author:

Hasan Yasmin,Furtado Larissa,Tergas Ana,Lee Nita,Brooks Rebecca,McCall Anne,Golden Daniel,Jolly Shruti,Fleming Gini,Morrow Matthew,Kraynyak Kimberly,Sylvester Albert,Arif Fauzia,Levin Matt,Schwartz David,Boyer Jean,Skolnik Jeffrey,Esser Mark,Kumar Rakesh,Bagarazzi Mark,Weichselbaum Ralph,Spiotto Michael

Funder

Inovio Pharmaceuticals, Inc and AstraZeneca

National Institutes of Health

National Institute of Dental and Craniofacial Research

Publisher

Elsevier BV

Subject

Cancer Research,Radiology Nuclear Medicine and imaging,Oncology,Radiation

Reference51 articles.

1. Human papillomavirus and cervical cancer;Crosbie;Lancet,2013

2. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer;Morris;New Engl J Med,1999

3. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer;Rose;New Engl J Med,1999

4. Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors;Arbyn;Cochrane Database Syst Rev,2018

5. Immunotherapy targeting HPV16/18 generates potent immune responses in hpv-associated head and neck cancer;Aggarwal;Clin Cancer Res,2019

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