Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii-induced cytokines in vitro

Author:

Ammerdorffer Anne,Stappers Mark H.T.,Oosting Marije,Schoffelen Teske,Hagenaars Julia C.J.P.,Bleeker-Rovers Chantal P.,Wegdam-Blans Marjolijn C.,Wever Peter C.,Roest Hendrik-Jan,van de Vosse Esther,Netea Mihai G.,Sprong Tom,Joosten Leo A.B.

Funder

The Netherlands Organization for Health Research and Development

European Research Council (ERC)

Publisher

Elsevier BV

Subject

Molecular Biology,Hematology,Biochemistry,Immunology,Immunology and Allergy

Reference26 articles.

1. Natural history and pathophysiology of Q fever;Raoult;Lancet Infect. Dis.,2005

2. Recognition of Coxiella burnetii by Toll-like receptors and nucleotide-binding oligomerization domain-like receptors;Ammerdorffer;J. Infect. Dis.,2014

3. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells;Chuang;Biochim. Biophys. Acta-Gene Struct. Expression,2001

4. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling;Guan;J. Immunol.,2010

5. Human TLR10 is an anti-inflammatory pattern-recognition receptor;Oosting;Proc. Natl. Acad. Sci. USA,2014

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