Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD-Reference-Cited by-同舟云学术

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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Published:2021-02 Issue:4 Volume:81 Page:767-783.e11
ISSN:1097-2765
Container-title:Molecular Cell
language:en
Short-container-title:Molecular Cell

Author:

Hewitt Graeme,Borel Valerie,Segura-Bayona Sandra,Takaki Tohru,Ruis Phil,Bellelli Roberto,Lehmann Laura C.,Sommerova Lucia,Vancevska Aleksandra,Tomas-Loba Antonia,Zhu Kang,Cooper Christopher,Fugger Kasper,Patel Harshil,Goldstone Robert,Schneider-Luftman Deborah,Herbert Ellie,Stamp Gordon,Brough Rachel,Pettitt Stephen,Lord Christopher J.,West Stephen C.,Ahel Ivan,Ahel Dragana,Chapman J. Ross,Deindl Sebastian,Boulton Simon J.

Funder

Cancer Research UK

Medical Research Council

Wellcome Trust

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference53 articles.

1. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1;Ahel;Science,2009

2. Excision of uracil from DNA by hSMUG1 includes strand incision and processing;Alexeeva;Nucleic Acids Res.,2019

3. Polepsilon Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis;Bellelli;Mol. Cell,2018

4. Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin;Bilokapic;Nature,2020

5. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase;Bryant;Nature,2005

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