Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

Author:

Wilson Gemma A.,Vuina Karla,Sava Georgina,Huard Caroline,Meneguello Leticia,Coulombe-Huntington Jasmin,Bertomeu Thierry,Maizels Rory J.,Lauring Josh,Kriston-Vizi Janos,Tyers Mike,Ali Simak,Bertoli Cosetta,de Bruin Robertus A.M.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference49 articles.

1. Cell cycle control in cancer;Matthews;Nat. Rev. Mol. Cell Biol.,2022

2. CDK7 inhibitors as anticancer drugs;Sava;Cancer Metastasis Rev.,2020

3. ICEC0942, an orally bioavailable selective inhibitor of CDK7 for cancer treatment;Patel;Mol. Cancer Ther.,2018

4. ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942;Sava;Oncogene,2020

5. Carrick Therapeutics receives FDA fast track designations for two samuraciclib combinations for the treatment of HR+, HER2lJ advanced breast cancer and locally advanced or metastatic triple negative breast cancer,2021

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