Synthesis, modelling, and μ-opioid receptor affinity of N-3(9)-arylpropenyl-N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes

Author:

Pinna G.A,Murineddu G,Curzu M.M,Villa S,Vianello P,Borea P.A,Gessi S,Toma L,Colombo D,Cignarella G

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmaceutical Science

Reference16 articles.

1. Bicyclic homologs of piperazine. VII. Synthesis and analgesic activity of 3-aralkenyl-8-propionyl-3,8-diaza-bicyclo[3.2.1]octanes;Cignarella;J. Med. Chem.,1965

2. Interaction of 3,8-diazabicyclo[3.2.1]octanes with μ and δ-opioid receptors;Cignarella;Pharmacol. Res. Commun.,1988

3. Computer aided structure-affinity relationships in a set of piperazine and 3,8- diazabicyclo[3.2.1]octane derivatives binding to the μ opioid receptor;Barlocco;J. Comput.-Aided Mol. Design,1993

4. Ricerche sui 3,9-diazabiciclo[3.3.1]nonani. Stereochimica e attività analgesica nei derivati del 3,9-diazabiciclo[3.3.1]nonanoe nel 3,8-diazabiciclo[3.2.1]ottano;Cignarella;Gazz. Chim. Ital.,1963

5. Antinociceptive action of DBO 17 and DBO 11 in mice: two 3,8-diazabicyclo[3.2.1]octane derivatives with selective μ opioid receptor affinity;Fadda;Naunyn-Schmiedeberg's Arch. Pharmacol.,1997

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