The combination of Nutlin-3 and Tanshinone IIA promotes synergistic cytotoxicity in acute leukemic cells expressing wild-type p53 by co-regulating MDM2-P53 and the AKT/mTOR pathway-Reference-Cited by-同舟云学术

The combination of Nutlin-3 and Tanshinone IIA promotes synergistic cytotoxicity in acute leukemic cells expressing wild-type p53 by co-regulating MDM2-P53 and the AKT/mTOR pathway

Published:2019-01 Issue: Volume:106 Page:8-20
ISSN:1357-2725
Container-title:The International Journal of Biochemistry & Cell Biology
language:en
Short-container-title:The International Journal of Biochemistry & Cell Biology

Author:

Guo Yong,Li Yi,Wang Fang-Fang,Xiang Bing,Huang Xiao-Ou,Ma Hong-Bing,Gong Yu-Ping

Funder

National Natural Science Foundation of China

Foundation of Institutes of Health Department of Sichuan Province

Publisher

Elsevier BV

Subject

Cell Biology,Biochemistry

Reference46 articles.

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4. Tanshinone IIA affects autophagy and apoptosis of glioma cells by inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway;Ding;Pharmacology,2017

5. Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells;Ellington;Carcinogenesis,2006

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