Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines

Author:

Temmink Olaf H.,de Bruin Michiel,Turksma Annelies W.,Cricca Silvia,Laan Adrie C.,Peters Godefridus J.

Publisher

Elsevier BV

Subject

Cell Biology,Biochemistry

Reference49 articles.

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2. Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells;Aherne;Biochemical Pharmacology,1996

3. Uridine phosphorylase: An important enzyme in pyrimidine metabolism and fluoropyrimidine activation;Cao;Drugs of Today (Barc.),2004

4. Uridine phosphorylase (−/−) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines;Cao;Cancer Research,2002

5. Potentiation of 5-fluoro-2′-deoxyuridine antineoplastic activity by the uridine phosphorylase inhibitors benzylacyclouridine and benzyloxybenzylacyclouridine;Chu;Cancer Research,1984

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