S1P1-selective agonist prodrug IMMH002 is phosphorylated in rats to form an S-configured enantiomer: Synthesis, verification, and biological activity of the in vivo active metabolite-Reference-Cited by-同舟云学术

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S1P1-selective agonist prodrug IMMH002 is phosphorylated in rats to form an S-configured enantiomer: Synthesis, verification, and biological activity of the in vivo active metabolite

Published:2020-06 Issue:11 Volume:30 Page:127141
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Xiao Qiong,Hu Minwan,Chen Si,Jin Jing,Li Li,Hu Jinping,Xie Ping,Yin Dali

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

2. Sphingosine 1-Phosphate Receptor Signaling

3. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

4. Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

5. Sphingolipids in Cell Signaling: Their Function as Receptor Ligands, Second Messengers, and Raft Constituents

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design and synthesis of analogues of the sphingosine-1-phosphate receptor 1 agonist IMMH001 with improved phosphorylation rate in human blood;Bioorganic & Medicinal Chemistry;2020-11

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