Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS-Reference-Cited by-同舟云学术

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Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS

Published:2023-05 Issue: Volume:87 Page:129256
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Dodd Cayden J.^ORCID,Chronister Keagan S.,Rathnayake Upendra,Parr Lauren C.,Li Kangjun,Chang Sichen,Mi Dehui,Days Emily L.,Bauer Joshua A.,Cho Hyekyung P.^ORCID,Boutaud Olivier^ORCID,Denton Jerod S.,Lindsley Craig W.^ORCID,Han Changho^ORCID

Funder

William K Warren Foundation

Vanderbilt-Ingram Cancer Center

National Institutes of Health

Vanderbilt Institute of Chemical Biology, School of Medicine, Vanderbilt University

National Cancer Institute

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Octameric stoichiometry of the KATP channel complex;Shyng;J Gen Physiol,1997

2. Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides;Wang;Nat Commun,2022

3. Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives;B., H. J.;Curr Med Chem,2006

4. The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener, in healthy male subjects;Zdravkovic;J Clin Pharmacol,2005

5. Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues;Dabrowski;Diabetologia,2003

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