Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials

Author:

Berger Olivier,Ortial Stéphanie,Wein Sharon,Denoyelle Séverine,Bressolle Françoise,Durand Thierry,Escale Roger,Vial Henri J.,Vo-Hoang YenORCID

Funder

European Commission

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference35 articles.

1. In World Malaria Report 2018. Geneva (Switzerland): World Health Organization; 2018. https://www.who.int/malaria/publications/world-malaria-report-2018/report/en/ (Last accessed: april 16, 2019).

2. In Status report on artemisinin resistance and ACT efficacy. Geneva (Switzerland): World Health Organization; August 2018. https://www.who.int/malaria/publications/atoz/artemisinin-resistance-august2018/en/ (Last accessed: october 18, 2018).

3. Lipids as drug targets for malaria therapy;Vial,2011

4. Antimalarial activity of compounds interfering with plasmodium falciparum phospholipid metabolism: comparison between mono- and bisquaternary ammonium salts;Calas;J Med Chem,2000

5. A chemical proteomics approach for the search of pharmacological targets of the antimalarial clinical candidate albitiazolium in Plasmodium falciparum using photocrosslinking and click chemistry;Penarete-Vargas;PLoS One,2014

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