Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: Discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype-Reference-Cited by-同舟云学术

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Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: Discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype

Published:2012-07 Issue:14 Volume:22 Page:4660-4664
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Pothier Julien,Riederer Markus A.,Peter Oliver,Leroy Xavier,Valdenaire Anja,Gnerre Carmela,Fretz Heinz

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Release of Prostaglandin D2into Human Airways during Acute Antigen Challenge

2. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP

3. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

4. The roles of the prostaglandin D2 receptors DP1 and CRTH2 in promoting allergic responses

5. Emerging roles of DP and CRTH2 in allergic inflammation

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