Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives-Reference-Cited by-同舟云学术

Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives

Published:2008-03 Issue:6 Volume:18 Page:2114-2121
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Costanzo Michael J.,Yabut Stephen C.,Zhang Han-Cheng,White Kimberley B.,de Garavilla Lawrence,Wang Yuanping,Minor Lisa K.,Tounge Brett A.,Barnakov Alexander N.,Lewandowski Frank,Milligan Cynthia,Spurlino John C.,Abraham William M.,Boswell-Smith Victoria,Page Clive P.,Maryanoff Bruce E.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference31 articles.

1. Mast Cell Tryptase β as a Target in Allergic Inflammation: An Evolving Story

2. Inhibitors of mast cell tryptase beta as therapeutics for the treatment of asthma and inflammatory disorders

3. Tryptase Inhibition

4. Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.

5. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study

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