Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan -muscarinic antagonists-Reference-Cited by-同舟云学术

Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan -muscarinic antagonists

Published:2017-08 Issue:15 Volume:27 Page:3576-3581
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Bender Aaron M.,Weiner Rebecca L.,Luscombe Vincent B.,Ajmera Sonia,Cho Hyekyung P.,Chang Sichen,Zhan Xiaoyan,Rodriguez Alice L.,Niswender Colleen M.,Engers Darren W.,Bridges Thomas M.,Conn P. Jeffrey,Lindsley Craig W.

Funder

NIH

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes

2. Synthesis and Pharmacology of Benzoxazines as Highly Selective Antagonists at M4 Muscarinic Receptors

3. Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson's Disease

4. Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia

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