Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity-Reference-Cited by-同舟云学术

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Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity

Published:2009-05 Issue:10 Volume:19 Page:2693-2698
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Jiang Sheng,Liao Chenzhong,Bindu Lakshman,Yin Biaolin,Worthy Karen W.,Fisher Robert J.,Burke Terrence R.,Nicklaus Marc C.,Roller Peter P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference38 articles.

1. The GRB family of SH2 domain proteins

2. Up-regulation of the protein tyrosine phosphatase SHP-1 in human breast cancer and correlation withGRB2 expression

3. Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells

4. Structure-based design of a non-peptidic antagonist of the SH2 domain of GRB2

5. Structural Requirements for Tyr in the Consensus Sequence Y-E-N of a Novel Nonphosphorylated Inhibitor to the Grb2-SH2 Domain

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