Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design-Reference-Cited by-同舟云学术

Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design

Published:2016-07 Issue:14 Volume:26 Page:3274-3277
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hughes Norman E.,Bleisch Thomas J.,Jones Scott A.,Richardson Timothy I.,Doti Robert A.,Wang Yong,Stout Stephanie L.,Durst Gregory L.,Chambers Mark G.,Oskins Jennifer L.,Lin Chaohua,Adams Lisa A.,Page Todd J.,Barr Robert J.,Zink Richard W.,Osborne Harold,Montrose-Rafizadeh Chahrzad,Norman Bryan H.

Funder

DOE Office of Science by Argonne National Laboratory

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. The Retinoids, Biology, Chemistry and Medicine;Sporn,1993

2. Articular cartilage degradation and de-differentiation of chondrocytes by the systemic administration of retinyl acetate-ectopic production of osteoblast stimulating factor-1 by chondrocytes in mice

3. Distinct Transglutaminase 2-independent and Transglutaminase 2-dependent Pathways Mediate Articular Chondrocyte Hypertrophy

4. Ligands for retinoic acid receptors are elevated in osteoarthritis and may contribute to pathologic processes in the osteoarthritic joint

5. The oral administration of retinoic acid enhances nociceptive withdrawal reflexes in rats with soft-tissue inflammation

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