Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide-Reference-Cited by-同舟云学术

Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide

Published:2011-07 Issue:14 Volume:21 Page:4150-4154
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Robinson Ralph P.,Bartlett Jeremy A.,Bertinato Peter,Bessire Andrew J.,Cosgrove Judith,Foley Patrick M.,Manion Tara B.,Minich Martha L.,Ramos Brenda,Reese Matthew R.,Schmahai Theodore J.,Swick Andrew G.,Tess David A.,Vaz Alfin,Wolford Angela

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference8 articles.

1. In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity

2. Dirlotapide: a review of its properties and role in the management of obesity in dogs

3. Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors

4. Pharmacological Characterization of Diethyl-2-({3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein

5. Novel microsomal triglyceride transfer protein inhibitors

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