The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead-Reference-Cited by-同舟云学术

The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead

Published:2010-12 Issue:24 Volume:20 Page:7421-7425
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Siu Tony,Kozina Ekaterina S.,Jung Joon,Rosenstein Craig,Mathur Anjili,Altman Michael D.,Chan Grace,Xu Lin,Bachman Eric,Mo Jan-Rung,Bouthillette Melaney,Rush Thomas,Dinsmore Christopher J.,Marshall C. Gary,Young Jonathan R.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Regulation of JAK–STAT signalling in the immune system

2. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

3. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

4. Fridman, J.; Nussenzveig, R.; Liu, P.; Rodgers, J.; Burn, T.; Haley, P.; Scherle, P.; Newton, R.; Hollis, G.; Freidman, S.; Verstovsek, S.; Vaddi, K. Blood, ASH Annual Meeting Abstracts, 2007, Abstr. 110, 3538.

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