Synthesis of PET probe O6-[(3-[11C]methyl)benzyl]guanine by Pd0-mediated rapid C-[11C]methylation toward imaging DNA repair protein O6-methylguanine-DNA methyltransferase in glioblastoma-Reference-Cited by-同舟云学术

Synthesis of PET probe O6-[(3-[11C]methyl)benzyl]guanine by Pd0-mediated rapid C-[11C]methylation toward imaging DNA repair protein O6-methylguanine-DNA methyltransferase in glioblastoma

Published:2017-05 Issue:9 Volume:27 Page:1892-1896
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Koyama Hiroko,Ikenuma Hiroshi,Toda Hiroshi,Kondo Goro,Hirano Masaki,Kato Masaya,Abe Junichiro,Yamada Takashi,Wakabayashi Toshihiko,Ito Kengo,Natsume Atsushi,Suzuki Masaaki

Funder

Japan Society for the Promotion of Science

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. The fundamental role of epigenetic events in cancer

2. MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

3. IFN-β Down-Regulates the Expression of DNA Repair Gene MGMT and Sensitizes Resistant Glioma Cells to Temozolomide

4. Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase

5. Directed Evolution of O6-Alkylguanine-DNA Alkyltransferase for Efficient Labeling of Fusion Proteins with Small Molecules In Vivo

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and evaluation of a novel PET ligand, a GSK’963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain;EJNMMI Radiopharmacy and Chemistry;2023-10-18

2. Identification of AGT and CD44 in methotrexate-resistant colorectal cancer and reversal of methotrexate-resistance;Pathology - Research and Practice;2022-01

3. Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery;Nature;2020-11-25

4. Green Process of Three-Component Prostaglandin Synthesis and Rapid ¹¹C Labelings for Short-Lived PET Tracers;Green Process of Three-Component Prostaglandin Synthesis and Rapid ¹¹C Labelings for Short-Lived PET Tracers;2018-01-31

5. Discriminating MGMT promoter methylation status in patients with glioblastoma employing amide proton transfer-weighted MRI metrics;European Radiology;2017-12-12