Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility-Reference-Cited by-同舟云学术

Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility

Published:2006-01 Issue:1 Volume:16 Page:44-48
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ban Hitoshi,Muraoka Masami,Ioriya Katsuhisa,Ohashi Naohito

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. Role of acylcoenzyme A: Cholesterol o-acyltransferase in cholesterol metabolism

2. Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.

3. Effect of dietary fat saturation, cholesterol and cholestyramine on acyl-CoA: Cholesterol acyltransferase activity in rabbit intestinal microsomes

4. Role of acyl CoA:cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in the rabbit.

5. Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification

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