The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2

Published:2006-02 Issue:4 Volume:16 Page:1060-1064
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Kohrt Jeffrey T.,Filipski Kevin J.,Cody Wayne L.,Cai Cuiman,Dudley Danette A.,Van Huis Chad A.,Willardsen J. Adam,Narasimhan Lakshmi S.,Zhang Erli,Rapundalo Stephen T.,Saiya-Cork Kamlai,Leadley Robert J.,Edmunds Jeremy J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference34 articles.

1. Regulation of the extrinsic pathway system in health and disease: The role of factor VIIa and tissue factor pathway inhibitor

2. Initiation of blood coagulation: the tissue factor/factor VIIa complex

3. New Insights into How Blood Clots: Implications for the Use of APTT and PT as Coagulation Screening Tests and in Monitoring of Anticoagulant Therapy

4. The Tissue Factor Pathway: How It Has Become a “Prima Ballerina”

5. Active site-blocked activated factor VII as an effective antithrombotic agent: mechanism of action

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1. Synthesis of acyclic triarylmethane-based compounds containing perfluoropyridine subunits using 4,4′-(p-tolylmethylene)bis(2,6-dimethylphenol) as a flexible spacer;Journal of Molecular Structure;2024-04

2. Site-selective nucleophilic substitution reactions of pentafluoropyridine with hydroxybenzaldehydes: synthesis of triarylmethanes comprising perfluoropyridine moieties;New Journal of Chemistry;2023

3. Evaluation of Serine Protease Inhibitors as Potent FVIIa-sTF Inhibitors in the Blood Coagulation Cascade;Letters in Drug Design & Discovery;2015-10-30

4. Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors;Journal of Medicinal Chemistry;2015-07-28

5. Synthesis and in vitro anticoagulant activity of 3-(1H-imidazo[4,5-c]pyridin-2-yl)-1,5-diarylpyridin-2(1H)-one derivatives;Research on Chemical Intermediates;2015-02-06