Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy-Reference-Cited by-同舟云学术

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Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy

Published:2006-01 Issue:2 Volume:16 Page:252-256
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Masterson Luke A.,Spanswick Victoria J.,Hartley John A.,Begent Richard H.,Howard Philip W.,Thurston David E.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. The chemotherapy of cancer;Thurston,2005

2. Prodrug strategies in cancer therapy

3. Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material

4. SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity

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2. Matrixmetalloproteinase Inhibitors: Promising Therapeutic Targets Against Cancer;Current Pharmaceutical Design;2021-11-19

3. Antibody-drug conjugates (ADCs) delivering pyrrolobenzodiazepine (PBD) dimers for cancer therapy;Expert Opinion on Biological Therapy;2020-06-16

4. 1,4-Diazepines: A Review on Synthesis, Reactions and Biological Significance;Current Organic Synthesis;2019-10-17

5. One-pot tandem cyclisation to pyrrolo[1,2-a][1,4]benzodiazepines: a modified approach to the Pictet–Spengler reaction;Organic & Biomolecular Chemistry;2019

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