Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration-Reference-Cited by-同舟云学术

Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration

Published:2021-03 Issue: Volume:36 Page:127821
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Fiolek Taylor J.,Magyar Christina L.^ORCID,Wall Tyler J.^ORCID,Davies Steven B.^ORCID,Campbell Molly V.,Savich Christopher J.,Tepe Jetze J.,Mosey R. Adam

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference59 articles.

1. Neurodegenerative disease: brain windfall;Gammon;Nature,2014

2. Neurodegenerative disease: models, mechanisms, and a new hope

3. Drugging the ‘undruggable’ cancer targets;Dang;Nat Rev Cancer,2017

4. Drugging Undruggable Molecular Cancer Targets;Lazo;Annu Rev Pharmacol Toxicol,2016

5. Untapped Potential of Disordered Proteins in Current Druggable Human Proteome;Hu;Curr Drug Targets,2016

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. 20S proteasome enhancers prevent cytotoxic tubulin polymerization-promoting protein induced α-synuclein aggregation;iScience;2024-07

2. Rpt5-Derived Analogs Stimulate Human Proteasome Activity in Cells and Degrade Proteins Forming Toxic Aggregates in Age-Related Diseases;International Journal of Molecular Sciences;2024-04-25

3. Ubiquitin E3 ligases assisted technologies in protein degradation: Sharing pathways in neurodegenerative disorders and cancer;Ageing Research Reviews;2024-04

4. Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins;Bioorganic Chemistry;2024-04

5. Direct Formation of C–C, C–N, and C–O Bonds in Dihydroquinazolines via Hypervalent Iodine(III)-Mediated sp³ C–H Functionalization;The Journal of Organic Chemistry;2024-01-02