Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors

Author:

Axford Lorraine C.,Agarwal Piyush K.,Anderson Kelly H.,Andrau Laura N.,Atherall John,Barker Stephanie,Bennett James M.,Blair Michael,Collins Ian,Czaplewski Lloyd G.,Davies David T.,Gannon Carlie T.,Kumar Dushyant,Lancett Paul,Logan Alastair,Lunniss Christopher J.,Mitchell Dale R.,Offermann Daniel A.,Palmer James T.,Palmer Nicholas,Pitt Gary R.W.,Pommier Stéphanie,Price Daniel,Narasinga Rao B.,Saxena Rashmi,Shukla Tarun,Singh Amit K.,Singh Mahipal,Srivastava Anil,Steele Christopher,Stokes Neil R.,Thomaides-Brears Helena B.,Tyndall Edward M.,Watson David,Haydon David J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference9 articles.

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2. DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities

3. Designing Multi-Target Drugs;East,2012

4. Haydon, D.J.; Czaplewski, L.G.; Palmer, N.J.; Mitchell, D.R.; Atherall, J.F.; Steele, C.R.; Ladduwahetty, T.; PCT Int. Appl. WO2007/148093.

5. Haydon, D.J.; Czaplewski, L.G.; PCT Int. Appl. WO2009/074810.

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