Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase-Reference-Cited by-同舟云学术

Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Published:2010-03 Issue:5 Volume:20 Page:1680-1684
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Wurz Ryan P.,Pettus Liping H.,Henkle Bradley,Sherman Lisa,Plant Matthew,Miner Kent,McBride Helen J.,Wong Lu Min,Saris Christiaan J.M.,Lee Matthew R.,Chmait Samer,Mohr Christopher,Hsieh Faye,Tasker Andrew S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. Is there a future for small molecule drugs in the treatment of rheumatic diseases?

2. Therapeutic potential of inhaled p38 mitogen-activated protein kinase inhibitors for inflammatory pulmonary diseases

3. The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis

4. Chemical Genetics Define the Roles of p38α and p38β in Acute and Chronic Inflammation

5. Small Molecule p38 MAP Kinase Inhibitors for the Treatment of Inflammatory Diseases: Novel Structures and Developments During 2006- 2008

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