Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors-Reference-Cited by-同舟云学术

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

Published:2009-08 Issue:15 Volume:19 Page:4088-4091
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Owen Dafydd R.,Walker John K.,Jon Jacobsen E.,Freskos John N.,Hughes Robert O.,Brown David L.,Bell Andrew S.,Brown David G.,Phillips Christopher,Mischke Brent V.,Molyneaux John M.,Fobian Yvette M.,Heasley Steve E.,Moon Joseph B.,Stallings William C.,Joseph Rogier D.,Fox David N.A.,Palmer Michael J.,Ringer Tracy,Rodriquez-Lens Margarita,Cubbage Jerry W.,Blevis-Bal Radhika M.,Benson Alan G.,Acker Brad A.,Maddux Todd M.,Tollefson Michael B.,Bond Brian R.,MacInnes Alan,Yu Yung

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

2. Cyclic GMP Phosphodiesterase-5: Target of Sildenafil

3. Phosphodiesterase Type 5 (PDE5) Inhibitors

4. Chapter 6. Phosphodiesterase 5 inhibitors

5. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond

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