Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092-Reference-Cited by-同舟云学术

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Published:2012-11 Issue:21 Volume:22 Page:6694-6699
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Bahl Ash,Barton Patrick,Bowers Keith,Caffrey Moya V.,Denton Rebecca,Gilmour Peter,Hawley Shaun,Linannen Tero,Luckhurst Christopher A.,Mochel Tobias,Perry Matthew W.D.,Riley Robert J.,Roe Emma,Springthorpe Brian,Stein Linda,Webborn Peter

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

2. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

3. Cutting Edge: Expression of the C-C Chemokine Receptor CCR3 in Human Airway Epithelial Cells

4. CCR3 Expression and Function in Asthmatic Airway Smooth Muscle Cells

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Methyl-Containing Pharmaceuticals;Pharmaceuticals;2024-04-28

2. Methylation in hangtaimycin biosynthesis and its antibacterial activities;Synthetic and Systems Biotechnology;2023-12

3. Agents for the Treatment of Gout: Current Advances and Future Perspectives;Journal of Medicinal Chemistry;2023-11-01

4. A High‐Throughput Continuous Spectroscopic Assay to Measure the Activity of Natural Product Methyltransferases;ChemBioChem;2022-07-14

5. Lead optimization of pyrido[2,3–d][1]benzazepin-6-one derivatives leading to the discovery of a potent, selective, and orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist (DS69910557);Bioorganic & Medicinal Chemistry;2022-06