2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-ζ inhibitor-Reference-Cited by-同舟云学术

2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-ζ inhibitor

Published:2009-02 Issue:3 Volume:19 Page:908-911
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Trujillo John I.,Kiefer James R.,Huang Wei,Thorarensen Atli,Xing Li,Caspers Nicole L.,Day Jacqueline E.,Mathis Karl J.,Kretzmer Kuniko K.,Reitz Beverley A.,Weinberg Robin A.,Stegeman Roderick A.,Wrightstone Ann,Christine Lori,Compton Robert,Li Xiong

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. The extended protein kinase C superfamily

2. PKCζ at the crossroad of NF-κB and Jak1/Stat6 signaling pathways

3. Role of Protein Kinase C in Eosinophil Function

4. Protein Kinase Cζ Is Up-regulated in Osteoarthritic Cartilage and Is Required for Activation of NF-κB by Tumor Necrosis Factor and Interleukin-1 in Articular Chondrocytes

5. Involvement of protein kinase Cζ in interleukin-1β induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-κB signaling in primary human osteoarthritic chondrocytes

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