Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems-Reference-Cited by-同舟云学术

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems

Published:2017-08 Issue:15 Volume:27 Page:3219-3225
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Llona-Minguez Sabin^ORCID,Häggblad Maria,Martens Ulf,Johansson Lars,Sigmundsson Kristmundur,Lundbäck Thomas,Loseva Olga,Jemth Ann-Sofie,Lundgren Bo,Jensen Annika Jenmalm,Scobie Martin,Helleday Thomas

Funder

Swedish Research Council

Knut and Alice Wallenberg Foundation

Göran Gustafsson Foundation

Swedish Pain Relief Foundation

Torsten Söderbergs Stiftelse

Children's Cancer Foundation

Swedish Cancer Society

Karolinska Institutet

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference32 articles.

1. Dimeric dUTPases, HisE, and MazG belong to a New Superfamily of all-α NTP Pyrophosphohydrolases with Potential “House-cleaning” Functions

2. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

3. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

4. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

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