Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors-Reference-Cited by-同舟云学术

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

Published:2004-06 Issue:11 Volume:14 Page:2817-2822
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Baxter Andrew,Brough Steve,Cooper Anne,Floettmann Eike,Foster Steve,Harding Christine,Kettle Jason,McInally Tom,Martin Craig,Mobbs Michelle,Needham Maurice,Newham Pete,Paine Stuart,St-Gallay Steve,Salter Sylvia,Unitt John,Xue Yafeng

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

2. Activators and target genes of Rel/NF-κB transcription factors

3. The Rel/NF-κB family: friend and foe

4. The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

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