Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein E production-Reference-Cited by-同舟云学术

Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein E production

Published:2012-10 Issue:19 Volume:22 Page:6252-6255
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Singh Mandeep,Schott Jason T.,Leon Martin A.,Granata Robert T.,Dhah Harkiran K.,Welles Jason A.,Boyce Michelle A.,Oseni-Olalemi Hafeez S.,Mordaunt Charles E.,Vargas Anthony J.,Patel Nilay V.,Maitra Santanu

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease

2. ApoE genotype accounts for the vast majority of AD risk and AD pathology

3. Apolipoprotein E: Far More Than a Lipid Transport Protein

4. Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans

5. ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

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