Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors-Reference-Cited by-同舟云学术

Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors

Published:2008-01 Issue:2 Volume:18 Page:721-725
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Langford H. Marie,Williams Peter D.,Homnick Carl F.,Vacca Joseph P.,Felock Peter J.,Stillmock Kara A.,Witmer Marc V.,Hazuda Daria J.,Gabryelski Lori J.,Schleif William A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. HIV-1 Integrase: A Target for New AIDS Chemotherapeutics

2. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial

3. Raltegravir: a new antiretroviral class for salvage therapy

4. Miller, M.; Witmer, M.; Stillmock, K.; Felock, P.; Ecto, L.; Flynn, J.; Schleif, W.; Donradula, G.; Danovich, R.; Hazuda, D. International AIDS Conference, 2006, Toronto, Canada, Abstract No. ThAa0302.

5. 8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors

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