Studies on the structure–activity relationship of 2′,6′-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H–Dmt–NH

Studies on the structure–activity relationship of 2′,6′-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H–Dmt–NH–CH3

Published:2005-02 Issue:3 Volume:15 Page:599-602
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Fujita Yoshio,Tsuda Yuko,Motoyama Takashi,Li Tingyou,Miyazaki Anna,Yokoi Toshio,Sasaki Yusuke,Ambo Akihiro,Niizuma Hideko,Jinsmaa Yunden,Bryant Sharon D.,Lazarus Lawrence H.,Okada Yoshio

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference37 articles.

1. Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.

2. Dynorphin-(1-13), an extraordinarily potent opioid peptide.

3. Identification of two related pentapeptides from the brain with potent opiate agonist activity

4. A potent and selective endogenous agonist for the µ-opiate receptor

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications;Chemical Reviews;2017-06-27

2. Developmental Potential for Endomorphin Opioidmimetic Drugs;International Journal of Medicinal Chemistry;2012-06-15

3. Design and synthesis of opioidmimetics containing 2′,6′-dimethyl-l-tyrosine and a pyrazinone-ring platform;Bioorganic & Medicinal Chemistry Letters;2007-11

4. Synthesis of Opioidmimetics, 3-[H-Dmt-NH(CH2)m]-6-[H-Dmt-NH(CH2)n]-2(1H)-pyrazinones, and Studies on Structure-Activity Relationships;Medicinal Chemistry;2007-11-01

5. Endogenous opiates and behavior: 2005;Peptides;2006-12