The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: A new class of Aurora-A kinase inhibitors-Reference-Cited by-同舟云学术

The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: A new class of Aurora-A kinase inhibitors

Published:2006-11 Issue:22 Volume:16 Page:5778-5783
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Moriarty Kevin J.,Koblish Holly K.,Garrabrant Thomas,Maisuria Jahanvi,Khalil Ehab,Ali Farah,Petrounia Ioanna P.,Crysler Carl S.,Maroney Anna C.,Johnson Dana L.,Galemmo Robert A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis

2. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

3. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

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