Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site-Reference-Cited by-同舟云学术

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Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site

Published:2022-03 Issue: Volume:60 Page:128571
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Yan Nicholas L.^ORCID,Nair Reji^ORCID,Chu Alan,Wilson Ian A.,Johnson Kristen A.^ORCID,Morgan Gareth J.^ORCID,Kelly Jeffery W.^ORCID

Funder

Office of Science

Argonne National Laboratory

NIH

U.S. Department of Energy

National Institute of General Medical Sciences

National Cancer Institute

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference35 articles.

1. Systemic amyloidosis;Wechalekar;Lancet,2016

2. Immunoglobulin light chain amyloidosis;Merlini;Expert Rev Hematol,2014

3. Systemic immunoglobulin light chain amyloidosis;Merlini;Nat Rev Dis Prim,2018

4. Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients;Blancas-Mejía;Biophys Chem,2017

5. The kinetic stability of a full-length antibody light chain dimer determines whether endoproteolysis can release amyloidogenic variable domains;Morgan;J Mol Biol,2016

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Native State Stabilization of Amyloidogenic Proteins by Kinetic Stabilizers: Inhibition of Protein Aggregation and Clinical Relevance;ChemMedChem;2024-08-23

2. Understanding and Overcoming Biochemical Diversity in AL Amyloidosis;Israel Journal of Chemistry;2023-11-06

3. Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis;Current Opinion in Chemical Biology;2023-08

4. Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe;Frontiers in Immunology;2023-07-13

5. Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand‐Binding Cavity;Israel Journal of Chemistry;2023-04-12

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