Discovery of novel PTHR1 antagonists: Design, synthesis, and structure activity relationships
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference22 articles.
1. Progress, Paradox, and Potential: Parathyroid Hormone Research over Five Decades
2. Inhibition of the in vivo parathyroid hormone-mediated calcemic response in rats by a synthetic hormone antagonist.
3. Novel Parathyroid Hormone (PTH) Antagonists That Bind to the Juxtamembrane Portion of the PTH/PTH-related Protein Receptor
4. The Influence of Target Family and Functional Activity on the Physicochemical Properties of Pre-Clinical Compounds
5. Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism
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1. Advances in structure-based drug design: The potential for precision therapeutics in psychiatric disorders;Neuron;2024-02
2. Lead optimization of pyrido[2,3–d][1]benzazepin-6-one derivatives leading to the discovery of a potent, selective, and orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist (DS69910557);Bioorganic & Medicinal Chemistry;2022-06
3. PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective;Journal of Cellular and Molecular Medicine;2021-03-06
4. Discovery of novel, potent, and orally bioavailable pyrido[2,3-d][1]benzazepin-6-one antagonists for parathyroid hormone receptor 1;Bioorganic & Medicinal Chemistry;2020-06
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