An investigation of targeted inhibition of transcription factor activity with pyrrole imidazole polyamide (PA) in chronic myeloid leukemia (CML) blast crisis cells

Author:

Hayatigolkhatmi K.,Padroni G.,Su W.,Fang L.,Gómez-Castañeda E.,Hsieh Y.C.,Jackson L.,Pellicano F.,Burley G.A.,Jørgensen H.G.

Funder

University of Strathclyde

Friends of Paul O'Gorman Leukaemia Research Centre

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference14 articles.

1. Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles;Fontaine;Cell Regeneration (London),2015

2. Antitumor activity of a pyrrole-imidazole polyamide;Yang;Proc Natl Acad Sci USA,2013

3. DNA minor groove binders as therapeutic agents;Withers;Compr Supramolecular Chemi II,2017

4. Sequence-specific DNA binding pyrrole–imidazole polyamides and their applications;Kawamoto;Bioorganic Med Chem,2018

5. Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding;Chenoweth;J Am Chem Soc,2010

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