Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold-Reference-Cited by-同舟云学术

Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold

Published:2008-10 Issue:19 Volume:18 Page:5259-5262
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Marsilje Thomas H.,Alper Phil B.,Lu Wenshuo,Mutnick Daniel,Michellys Pierre-Yves,He Yun,Karanewsky Donald S.,Chow Donald,Gerken Andrea,Lao Jianmin,Kim Min-Ju,Seidel H. Martin,Tian Shin-Shay

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference12 articles.

1. Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor

2. Eltrombopag

3. Eltrombopag for the Treatment of Chronic Idiopathic Thrombocytopenic Purpura

4. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist

5. Eltrombopag for Thrombocytopenia in Patients with Cirrhosis Associated with Hepatitis C

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