Discovery of potent and orally bioavailable heterocycle-based β3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity-Reference-Cited by-同舟云学术

Discovery of potent and orally bioavailable heterocycle-based β3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity

Published:2007-09 Issue:18 Volume:17 Page:5245-5250
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Lafontaine Jennifer A.,Day Robert F.,Dibrino Joe,Hadcock John R.,Hargrove Diane M.,Linhares Michael,Martin Kelly A.,Maurer Tristan S.,Nardone Nancy A.,Tess David A.,DaSilva-Jardine Paul

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. Carboxyl-promoted enhancement of selectivity for the β3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-β3 binding selectivity

2. Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

3. β3-adrenergic agonists: potential therapeutics for obesity

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