Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform-Reference-Cited by-同舟云学术

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform

Published:2013-05 Issue:9 Volume:23 Page:2606-2613
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Staben Steven T.,Ndubaku Chudi,Blaquiere Nicole,Belvin Marcia,Bull Richard J.,Dudley Danette,Edgar Kyle,Gray Daniel,Heald Robert,Heffron Timothy P.,Jones Graham E.,Jones Mark,Kolesnikov Aleks,Lee Leslie,Lesnick John,Lewis Cristina,Murray Jeremy,McLean Neville J.,Nonomiya Jim,Olivero Alan G.,Ord Rachel,Pang Jodie,Price Stephen,Prior Wei Wei,Rouge Lionel,Salphati Laurent,Sampath Deepak,Wallin Jeff,Wang Lan,Wei BinQing,Weismann Christian,Wu Ping

Funder

Baculovirus Expression Group at Genentech

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference29 articles.

1. Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase

2. Oxidative activation of the thiophene ring by hepatic enzymes

3. Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

4. First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives

5. Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. From lab to clinic: The discovery and optimization journey of PI3K inhibitors;European Journal of Medicinal Chemistry;2024-11

2. A comprehensive review on phosphatidylinositol-3-kinase (PI3K) and its inhibitors bearing pyrazole or indazole core for cancer therapy;Chemico-Biological Interactions;2024-08

3. QbD Approach to Process Characterization and Quantitative Criticality Assessment of Process Parameters;Organic Process Research & Development;2024-03-25

4. Identification of natural product as selective PI3Kα inhibitor against NSCLC: multi-ligand pharmacophore modeling, molecular docking, ADME, DFT, and MD simulations;Molecular Diversity;2023-09-15

5. Evaluation of antibacterial, antioxidant, cytotoxic, and acetylcholinesterase inhibition activities of novel [1,4] benzoxazepines fused to heterocyclic systems with a molecular modeling study;Medicinal Chemistry Research;2022-12-24