Novel hybrid molecules of 3,5-bis(benzylidene)-4-piperidones and dichloroacetic acid which demonstrate potent tumour-selective cytotoxicity

Author:

Hossain Mohammad,Das Swagatika,Das Umashankar,Doroudi Alireza,Zhu Jianfeng,Dimmock Jonathan R.

Funder

Indiana University

Maunders McNeil Foundation Inc.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. 3,5-Bis(3-dimethylaminomethyl-4-hydroxybenzylidene)-4-piperidone and related compounds induce glutathione oxidation and mitochondria-mediated cell death in HCT-116 cells;Addala;Bioorg Med Chem Lett.,2017

2. 3,5-Bis(3-alkylaminomethyl)-4-hydroxybenzylidene)-4-piperidones: a novel class of potent tumor-selective cytotoxins;Karki;J Med Chem.,2016

3. Comparative QSAR analysis of 3,5-bis(arylidene)-4-piperidone derivatives: the development of predictive cytotoxicity models;Edraki;Iran J Pharm Res.,2016

4. Chemical and biological activity of chalcones and other α, β-unsaturated carbonyl compounds;Majdt;Xenobiotica,2013

5. Synthesis and cytotoxic evaluation of mesna adducts of some 1-aryl-4,4-dimethyl-5-(1-piperidino)-1-penten-3-one hydrochlorides;Dimmock;Pharmazie.,1995

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