GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models-Reference-Cited by-同舟云学术

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models

Published:2013-12 Issue:23 Volume:23 Page:6459-6462
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Martinez-Perez Jose A.,Iyengar Smriti,Shannon Harlan E.,Bleakman David,Alt Andrew,Arnold Brian M.,Bell Michael G.,Bleisch Thomas J.,Castaño Ana M.,Del Prado Miriam,Dominguez Esteban,Escribano Ana M.,Filla Sandra A.,Ho Ken H.,Hudziak Kevin J.,Jones Carrie K.,Mateo Ana,Mathes Brian M.,Mattiuz Edward L.,Ogden Ann Marie L.,Simmons Rosa Maria A.,Stack Douglas R.,Stratford Robert E.,Winter Mark A.,Wu Zhipei,Ornstein Paul L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference38 articles.

1. The glutamate story

2. Synaptic plasticity of kainate receptors

3. A nomenclature for ligand-gated ion channels

4. Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord

5. Actions of kainate and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord

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1. Kainate Receptor Antagonists: Recent Advances and Therapeutic Perspective;International Journal of Molecular Sciences;2023-01-18

2. Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid;Journal of Medicinal Chemistry;2016-12-22

3. GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy;Bioorganic & Medicinal Chemistry Letters;2013-12