Hit-to-lead studies on benzimidazole inhibitors of ITK: Discovery of a novel class of kinase inhibitors-Reference-Cited by-同舟云学术

Hit-to-lead studies on benzimidazole inhibitors of ITK: Discovery of a novel class of kinase inhibitors

Published:2007-07 Issue:13 Volume:17 Page:3660-3665
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Snow Roger J.,Abeywardane Asitha,Campbell Scot,Lord John,Kashem Mohammed A.,Khine Hnin Hnin,King Josephine,Kowalski Jennifer A.,Pullen Steven S.,Roma Teresa,Roth Gregory P.,Sarko Christopher R.,Wilson Noel S.,Winters Michael P.,Wolak John P.,Cywin Charles L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. Identification, cloning, and characterization of a novel human T-cell- specific tyrosine kinase located at the hematopoietin complex on chromosome 5q

2. itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

3. Structure and Expression of Novel Protein-Tyrosine Kinases, EMB and EMT, in Hematopoietic Cells

4. Lck Phosphorylates the Activation Loop Tyrosine of the Itk Kinase Domain and Activates Itk Kinase Activity

5. Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

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