Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression-Reference-Cited by-同舟云学术

Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression

Published:2016-12 Issue:23 Volume:26 Page:5663-5668
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Dressman Bruce A.,Tromiczak Eric G.,Chappell Mark D.,Tripp Allie E.,Quimby Steven J.,Vetman Tatiana,Fivush Adam M.,Matt James,Jaramillo Carlos,Li Renhua,Khilevich Albert,Blanco Maria-Jesus,Smith Stephon C.,Carpintero Mercedes,de Diego José Eugenio,Barberis Mario,García-Cerrada Susana,Soriano José F.,Schkeryantz Jeffrey M.,Witkin Jeffrey M.,Wafford Keith A.,Seidel Wesley,Britton Thomas,Overshiner Carl D.,Li Xia,Wang Xu-Shan,Heinz Beverly A.,Catlow John T.,Swanson Steven,Bedwell David,Ornstein Paul L.,Mitch Charles H.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Efficacy and Tolerability of an mGlu2/3 Agonist in the Treatment of Generalized Anxiety Disorder

2. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

3. MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

4. AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

5. The Metabotropic Glutamate (mGLU)2/3 Receptor Antagonist LY341495 [2S-2-Amino-2-(1S,2S-2-carboxycyclopropyl-1-yl)-3-(xanth-9-yl)propanoic Acid] Stimulates Waking and Fast Electroencephalogram Power and Blocks the Effects of the mGLU2/3 Receptor Agonist LY379268 [(-)-2-Oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate] in Rats

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1. A Double Deprotonation Strategy for Cascade Annulations of Palladium–Trimethylenemethanes and Morita–Baylis–Hillman Carbonates to Construct Bicyclo[3.1.0]hexane Frameworks;Angewandte Chemie International Edition;2021-05-11

2. A Double Deprotonation Strategy for Cascade Annulations of Palladium–Trimethylenemethanes and Morita–Baylis–Hillman Carbonates to Construct Bicyclo[3.1.0]hexane Frameworks;Angewandte Chemie;2021-05-11

3. Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety;Bioorganic & Medicinal Chemistry Letters;2019-05

4. Organocatalytic Transannular Approach to Stereodefined Bicyclo[3.1.0]hexanes;The Journal of Organic Chemistry;2018-03-12

5. New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity;Neural Plasticity;2017