5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents

Author:

Huang Wenlin,Hulverson Matthew A.,Zhang Zhongsheng,Choi Ryan,Hart Kevin J.,Kennedy Mark,Vidadala Rama Subba Rao,Maly Dustin J.,Van Voorhis Wesley C.,Lindner Scott E.,Fan Erkang,Ojo Kayode K.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of Child Health and Human Development

United States Department of Agriculture National Institute of Food and Agriculture

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. Plasmodium knowlesi: The Fifth Human Malaria Parasite

2. The global distribution of clinical episodes of Plasmodium falciparum malaria

3. WHO World Malaria Report 2015. World Health Organization. World Malaria Report 2015, 1–280, 2015. Publications of the World Health Organization: Geneva, Switzerland.

4. An Intensive Longitudinal Cohort Study of Malian Children and Adults Reveals No Evidence of Acquired Immunity to Plasmodium falciparum Infection

5. Guidelines for the Treatment of Malaria. 3rd ed., WHO, Geneva, 2015, http://apps.who.int/iris/bitstream/10665/162441/1/9789241549127_eng.pdf?ua=1.

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