Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP-Reference-Cited by-同舟云学术

Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP

Published:2007-10 Issue:19 Volume:17 Page:5390-5395
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Coleman Paul J.,Schreier John D.,Cox Christopher D.,Fraley Mark E.,Garbaccio Robert M.,Buser Carolyn A.,Walsh Eileen S.,Hamilton Kelly,Lobell Robert B.,Rickert Keith,Tao Weikang,Diehl Ronald E.,South Vicki J.,Davide Joseph P.,Kohl Nancy E.,Yan Youwei,Kuo Lawrence,Prueksaritanont Thomayant,Li Chunze,Mahan Elizabeth A.,Fernandez-Metzler Carmen,Salata Joseph J.,Hartman George D.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Development of new cancer therapeutic agents targeting mitosis

2. Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

3. An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis

4. Targeted anti-mitotic therapies: can we improve on tubulin agents?

5. Ispinesib Mesilate

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